Click on the speaker to read title and abstract for their lecture (updates continuously).
Keynote speaker: Mark R Wiesner
Mark R Wiesner is a James B. Duke Professor of Civil and Environmental Engineering at Duke University, USA. Wiesner's research interests include membrane processes, nanostructured materials, transport and fate of nanomaterials in the environment, colloidal and interfacial processes, and environmental systems analysis.
Harri Alenius is a Professor of Molecular Toxicology at Karolinska Institutet. He is investigating how different environmental exposures, including environmental and endogenous microbes, nanomaterials and chemicals, affect human wellbeing. The aim of the research is to uncover the mechanisms behind the factors linking environmental exposures with immune tolerance and the breaking of immune tolerance. Harri Alenius has been a guest or visiting Professor at several universities, including Zhejiang University in China in 2015.
Ulla Vogel is Professor in Chemical Working Environment at the National Research Centre for the Working Environment (NFA) and Adjunct Professor in Nanosafety at the Technical University of Denmark. She is head of Danish Centre for Nanosafety and has worked with the toxicology of inhaled (nano)particles for 20 years with focus on cancer, cardiovascular disease and reprotoxicity. The Nanosafety research group at NFA is past and present partner in more than 20 EU projects related to nanosafety.
Lena Palmberg, MD is a Professor in Toxicology at Karolinska Institutet. The long term goal with her research is to lay the foundation for effective, future treatments through better understanding of the mechanisms behind chronic bronchitis and COPD (Chronic Obstructive Pulmonary Disease). Her research is also providing new knowledge on environmental factors that cause these diseases including exposure to particles/nanoparticles. She has developed advanced multicellular lung mucosa models including human primary cells as an important tool in her research. (Photographer: Ulf Sirborn).
Multi-cellular human lung models for toxicity testing
Abstract: It is important to develop and evaluate physiologically relevant lung mucosa models including both bronchial and alveolar mucosa models with primary human cells for assessing nanoparticles related health hazards. To develop these sophisticated airway wall models further, they can be co-cultured with fibroblast/endothelial cells and/or innate effector cells (macrophages) which not only mimic the in vivo-situation but also avoid the constant concern of species differences when using animal models. These models with multiple cell types enable us to study cell-to cell interactions and cross-talk between the cells. New approaches regarding exposure methods are needed to be able to expose the models cultured at air-liquid interface. Further, both acute and repeated exposures are important to mimic both acute and more chronic exposure situation. The models can be used to explore the interaction of exposure, therapeutic effects, innate immunity, protease/antiprotease balance and oxidative stress as well as the interactions of various cell types. Validation of the models will make it possible to develop a systematic in vitro-testing strategy in order to reduce the requirement for animal inhalation studies.
Mónica João de Barros Amorim
Mónica João de Barros Amorim is a Principal Investigator in Stress Biology at University of Aveiro in Portugal. She was the president of SETAC Europe (2014-2015). Present research area is soil nanotoxicology and exotoxicogenomics including the development of new microarray technologies.
Bengt Fadeel, M.D., Ph.D., is a Professor of Inflammation Research at the Institute of Environmental Medicine (IMM), Karolinska Institutet. He is an expert on toxicity assessment of engineered nanomaterials, with particular focus on immune effects. Prof. Fadeel also serves as the chair of the scientific expert panel of the national nanosafety platform, SweNanoSafe.
Govind Gupta is a Postdoc at Institute of Environmental Medicine (IMM), Karolinska institutet. He has expertise in the safety assessment of nanomaterials in human in vitro cell line models including understanding their mechanisms of toxicity. He also has interest in nano-eco-interactions and fate assessment of nanomaterials in environmental systems.
Tommy Cedervall is an Associate Professor at Dept. of Biochemistry and Structural Biology, Lund University. He has expertise in the interactions between biomolecules, mostly proteins and nanomaterials. Experienced in the characterization of the identity of bound proteins in biological fluids, the affinity between protein and nanomaterials, the stoichiometry, and structure and function of bound proteins.
Mikael Ekvall is a researcher at Biochemistry and Structural Biology, Lund University. Mikael has a PhD in biology and his expertise is aquatic ecology. Mikael's research focus on effects of nanomaterials on freshwater organisms and trophic transfer of nanomaterials.
Inger Odnevall Wallinder
Inger Odnevall Wallinder is a Professor at the Division of Surface and Corrosion Science at KTH Royal Institute of Technology. She has more than 20 years expertise in the characterization of surface and bulk properties of nano- and micron-sized metallic particles, surface reactivity, surface interactions with biomolecules, metal release and speciation in biological media, and links to toxicity, as well as colloidal stability and mobility and environmental fate of nanoparticles.
Jonas Hedberg is a Researcher and docent at the Division of Surface and Corrosion Science, KTH Royal Institute of Technology, Sweden. He has experience in corrosion, spectroscopy, and surfaces studies of interactions between nanoparticles and biological and environmental media.
Connections between natural organic matter adsorption, dissolution and electrochemistry for a selection of metal nanoparticles
Abstract: Environmental risk assessment of the diffuse dispersion of metal nanoparticles (NPs) requires knowledge on their environmental fate in terms of changes in particle characteristics and their transformation in contact with freshwater and similar media. This work describes how interactions with natural organic matter (NOM) and the electrochemical properties of metal NPs influence their dissolution and surface characteristics. Investigated NPs include copper, manganese, aluminum, tungsten carbide, tungsten carbide cobalt, and cobalt. NOM interactions were studied using dihydroxy benzoic acid (DHBA) and Suwannee River humic acid. For example, DHBA adsorbed via covalent bonding with NPs of copper and aluminum, which enhanced their degree of dissolution through weakening of the metal-oxygen bonds of the surface oxide. In all, this study shows that the comparison of NPs of different surface characteristics is a way to increase the knowledge on the environmental fate of NPs, useful in terms of improved understanding of dissolution mechanisms.
Rickard Arvidsson is an Associate Professor at the Dept of Technology Management and Economics, Chalmers University of Technology. He has an expertise in Life Cycle Assessment and Environmental Risk Assessment of nanomaterials.
Proxy measures for manufactured nanomaterials
Proxy measures are simple indicators able to provide early signs of environmental risk. Since environmental risk assessment of manufactures nanomaterials (MNMs) has proven challenging, the feasibility of using proxy measures was investigated. A literature review revealed a number of potential proxy measures for MNMs, which were further evaluated based on environmental relevance and data availability, resulting in a number of promising measures: production volume, release and a number of ecotoxicity measures. Two of these – production volume and short-term aquatic ecotoxicity – were employed in a proof-of-concept test for seven MNMs: titanium dioxide, cerium dioxide, zinc oxide, silver, silicon dioxide, carbon nanotubes and graphene. The proxy measures were feasible for a screening environmental assessment of these MNMs. The results from the test furthermore revealed that some of the MNMs had high production volume and one had high ecotoxicity, but none had both high production volume and ecotoxicity.
Anna Furberg is a PhD Student at the Dept. of Technology Management and Economics, Chalmers University of Technology, with an expertise in Life Cycle Assessment.
Societal flows of cemented tungsten carbide – the case of tire studs
Abstract: Cemented tungsten carbide (WC-Co) is applied in many different applications due to its properties of high hardness and toughness. Tire studs represent one such application and is used in many countries in order to increase the friction between the tires and the winter road. Previous studies have indicated emissions of WC-Co nanoparticles originating from tire stud use but the magnitude of these emissions remain unknown. This study conducted a material flow analysis for tungsten, which is the main constituent of the tire stud pins, and quantified WC-Co nanoparticle emissions from the use of tire studs in Sweden. The results show that 100% of the tungsten in tire studs become dissipated and that 0% is functionally recycled. A comparison of WC-Co nanoparticle emissions with emissions of some engineered nanomaterials in various applications in Sweden showed that the WC-Co nanoparticle emissions were larger than for e.g. nanosilver.
Zareen Abbas is an Associate Professor at the Dept of Chemistry and Molecular Biology, University of Gothenburg. He has expertise in modeling the interactions of nanoparticles with organic molecules in ionic solutions as well as nanoparticles interactions with artificial membranes. Analytical theories along with simulation methods such as Monte Carlo (MC) and Molecular Dynamics (MD) are used for modeling.
Åsa Boholm is a Professor at the School of Global Studies, University of Gothenburg. Her expertise is social science risk research.
Magnus Jansson is economics master, file. Dr in Psychology and Certified Psychologist. Magnus's research is primarily focused on decision making and financial assessments. He disputed 2011 at the University of Gothenburg with the dissertation "Psychological influences on adoption of socially responsible investment". The thesis examines the psychological motives and driving forces that influence investors to take ethical consideration into their investment decisions.
Frida Book is a PhD Student at Dept of Biological and Environmental Sciences, University of Gothenburg.
Toxicity screening of seven different types of commercial silica nanoparticles using cellular and organismic assays: importance of surface and size
Abstract: We show that seven different types of commercial, biocide-free, colloidal silica particles of nominal sizes between 7 and 100 nm with 3 different surface chemistries (Na-stabilized aluminized and silane-modified) are not toxic to the bacterium Pseudomonas putida, and the algae Raphidocelis subcapitata in the concentration range 5-500 mg/L. They are also not acutely toxic to Daphnia magna at concentrations up to 10 000 mg/L. Six silica particles are toxic to gill cell lines from Rainbow trout (Oncorhynchus mykiss), showing a clear concentration-response relationship with EC50 values between 13-92 mg/L. Toxicity increases with hydrodynamic sizes and is dependent on particle surface area. The average EC50 across the tested particles is 2.0 m2 (± 0.3 m2/L). Surface modifications clearly impact toxicity, with silane-modified particles being not cytotoxic.
Julián Alberto Gallego Urrea
Julián Gallego is a postdoctoral research fellow in the department of marine sciences and connected to the research group on marine environmental nanochemistry. His main research focus is in inorganic environmental aquatic chemistry with emphasis in analytical chemistry, colloidal chemistry and chemical modelling.
Joachim Sturve is an Associate Professor at the Department of Biological and Environmental Sciences, University of Gothenburg. The main aim of his work is to identify effects of, and track the presence of, pollutants in the environment. The research is focused on the field of aquatic toxicology and ecotoxicology in connection with physiological changes in aquatic organisms.
Begoña Espiña is the Leader of the Water Quality Research Group within the Department of Life Sciences at INL, International Iberian Nanotechnology Laboratory, Portugal. Dr. Espiña focuses her research on developing biosensors based on nanomaterials for capture of chemical contaminants in water as well as developing methods for nanomaterials’ fate, bioaccumulation and toxicity.
Evaluation of toxicity and bioaccumulation of commercial nanomaterials used in plastic industry in aquatic organisms.
Abstract: Last decade’s extensive development of novel nanomaterials have boosted a remarkable expansion potential for multiple industry sectors. Yet, current uncertainty in the regulatory framework, the limited literature available on their potential effects towards human health and environmental safety, and the scarce information on their specific properties have limited their use in the industry. Our research group has screened the in vivo toxicity in zebrafish embryos and, toxicity and bioaccumulation in mussels of different engineered nanoparticles that are already commercially incorporated in materials developed in the industrial sector of plastics improving their barrier, mechanical and/or conductive properties. This research is being developed in the framework of the funded project Interreg SUDOE-NanoDESK. NanoDESK aims to promote the investment in nanotechnology in a safe and sustainable way in the plastic sector, solving the current barriers by developing a set of tools to support decision making.
Dr Marco Monopoli is StAR Research Lecturer in the Department of Pharmaceutical and Medical Chemistry in the RCSI in Ireland, where he is establishing a multi-disciplinary centre focused to obtain a complete understanding of the mechanisms of interaction between nanomaterials and living systems essential for Nanomedicine, Nanotoxicology applications and to evaluate their Environmental Impact.
Michael Persson, Ph.D., MBA, joined Nouryon (i.e. former AkzoNobel Specialty Chemicals) 1989 and have had several manager positions within the RD&I organization. He is since 2012 acting as innovation manager at Nouryon and adjunct professor in silica chemistry at Department for Chemistry and Chemical Engineering, Chalmers University of Technology. The focus areas have been material and product development based on submicron and/or nanoparticles often in close co-operation with institutes and universities.
Anna Lennquist holds a PhD in ecotoxicology from the University of Gothenburg, Sweden. She also holds a degree in journalism from the same university and has a strong interest in communicating scientific findings to a wider audience. Anna joined ChemSec in 2011. She has focused on substitution since then, first in the development of the SUBSPORT project, and since 2013 as project manager of the SIN List. 2016-2018 she was also in charge of developing ChemSec Marketplace.
Åsalie Hartmanis is managing director of SwedNanoTech, an association for promoting Swedish nanotechnology to national and international stakeholders. She has a long experience of strategic and operational communication on an executive management level from both public and private organizations, as well as media. During her entire career, she has been working in the interface between research and business development. Åsalie Hartmanis holds a Master’s degree in Biotechnology from the Royal Institute of Technology, Stockholm, Sweden.
Heike Hellmold is currently the head of the Unit for Toxicology Sciences at Karolinska Institutet. The unit has been an integral part of Swetox, an academic consortium of eleven universities with focus on collaboration in the area of chemicals, health and environment. She has a PhD in molecular toxicology and comprehensive experience of safety assessment of pharmaceuticals at AstraZeneca. During the past 3 years Heike has lead the startup of the Swedish National Platform for Nanosafety, SweNanoSafe and is also the Chair of the Cooperation Council for SweNanoSafe.